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- W2352953317 abstract "Objective: TO study the effects of perioperative useof cimetidine on natural killer (NK) cells in gastrointestinal (GI) cancer patients. Methods: 49 GI cancerpatients were randomized into treatment group whithtook cimetidine in the perioperative period, and controlgroup which did not take the drug. NK cells weremeasured by immunocytochemical method, usingmouse-anti-human CD57 monoclonal antibody as theprimary antibody. Blood samples from 20 healthyvolunteers were treated in the same way as normalcontrol. Comparisons were made within and betweengroups. Results: The NK cell percentage of normalcontrol was 18.50n.31. Both groups of Patients hadsignificantly lower than normal NK percentages beforetreatment (P0.05). NK cell percentages at admission,before operation, on the 2nd and the 10th postoperativedays were 14.60±91, 15.64±3.61, 17.40±3.28, 20.68±4.13, respectively, for the treatment group, and 14.8812.76, 13.17±2.93, 14.50±2.77, 15.67±2.55, respectively,for control group. The difference between the twogroups was statistically significant. Conclusion: Perioperative cimetidine application can help restore NKcells. The drug may be useful to reverse postoperativeimmuno-depression in GI cancer patients." @default.
- W2352953317 created "2016-06-24" @default.
- W2352953317 creator A5017193282 @default.
- W2352953317 date "1999-01-01" @default.
- W2352953317 modified "2023-09-26" @default.
- W2352953317 title "EFFECTS OF PERIOPERATIVE CIMETIDINE ADMINISTRATIONON NATURAL KILLER CELLS IN PATIENTS WITHGASTROINTESTINAL CANCER" @default.
- W2352953317 hasPublicationYear "1999" @default.
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