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- W2352961486 abstract "Objective:To study the effects and mechanism of Chinese Angelica against radiation-induced lung injury in rats.Methods:Rats in Groups A,B and C were exposed to 6 Mv X-rays at a dose of 20 Gy thoracically.The rats in Groups B and C were treated with angelica and dexamethasone respectively by gastrogavage one time a day just after X-ray exposure.The rats were sacrificed at day 5,15,30,45 and 60 after X-ray exposure.Pathological observation was performed after the lung tissues were treated with HE and Masson staining.The levels of superoxide dismutase(SOD),malondialdehyde(MDA)and hydroxyproline(HP)in lung tissues were measured simultaneously.Results:The inflammations in Groups B and C were much slighter compared with Group A.Collagenous fibers proliferation was found in the interstitial lung tissues on day 60 in Groups A and C,but not in Group B.SOD activities in lung tissues of rats in Group B began increasing significantly on day 45 and 60 after X-ray exposure compared with Group A(P0.01).MDA in lung tissues in group B began decreasing significantly on day 60 after X-ray exposure compared with Group A(P0.01).On day 60 after X-ray exposure,HP levels in lung tissues of Groups A and C were significantly higher than in Group D(P0.05).Conclusions:Angelica may improve the inflammatory reaction of radiation-induced lung injury and reduce pulmonary fibrosis caused by radiation injury.The mechanism of angelica of anti-inflammation and anti-fibrosis may possibly result from its potent anti-oxidation effects." @default.
- W2352961486 created "2016-06-24" @default.
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- W2352961486 date "2011-01-01" @default.
- W2352961486 modified "2023-09-23" @default.
- W2352961486 title "Experimental research of Chinese Angelica in rats with radiation-induced lung injury" @default.
- W2352961486 hasPublicationYear "2011" @default.
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