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- W2352967818 abstract "Objective To explore the effect of boron neutron capture therapy(BNCT)on G422 glioma.Methods Intracranial G422 glioma models were established through the injection of G422 cells into the mice brains.The ~(10)B concentrations for different tissues of tumor-bearing mice were determined by inductively coupled plasma atomic emission spectroscopy (ICP-AES).The tumor-bearing mice were randomly allocated into seven groups:unirradiated group (0 Gy),γ-ray control groups (5,10 Gy),reactor groups (5,10 Gy) and BNCT groups (5,10 Gy).The median survival time (MeST) and mean survival time (MST) were regarded as the evaluation indicators of therapeutic effects;the Kaplan-Meier survival curve was plotted to reflect the surviving process of each group;the percentage for increased life span (ILS,%) was calculated by the formula put forward by Barth.Results The ~(10)B concentration in tumor tissues reached the peak value of (43.78±3.02)μg/g at 1.5 h after intraperitoneal injection of boronophenylalanine (BPA) in the tumor-bearing mice.The percentages for increased life span of the mice with transplanted G422 glioma were respectively 235% (233%) and 329% (342%) in the BNCT groups (5,10 Gy).The survival rate of the 5-Gy BNCT group differed from that of the unirradiated group, 5-Gyγ-ray group and 5-Gy reactor group significantly (P0.05).And,the survival rate of 10-Gy BNCT group differed from that of the unirradiated group,5-Gyγ-ray group,10-Gyγ-ray group,5-Gy reactor group,10-Gy reactor group and 5-Gy BNCT group significantly (P0.05).Conclusion BNCT is an efficient therapy,which can improve the survival rate of mice bearing G422 glioma significantly in a dose-dependent manner.Compared withγ-ray irradiation,a higher relative biological effectiveness (RBE) can be achieved in vivo by BNCT." @default.
- W2352967818 created "2016-06-24" @default.
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- W2352967818 date "2007-01-01" @default.
- W2352967818 modified "2023-09-28" @default.
- W2352967818 title "Boron neutron capture therapy for the treatment of G422 glioma" @default.
- W2352967818 hasPublicationYear "2007" @default.
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