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- W2352982425 abstract "Objective:To study dynamic pathology changes of cholestatic cirrhosis in rats.Methods:Cholestatic cirrhosis in rats was duplicated by ligation of bile duct,rats were sacrificed after 3d,1W,2W,3W,4W and 5W of ligation for dynamic study histological changes,liver function,Hyp content in liver tissue and CK-19 expression in proliferated bile duct were determined with HE staining,biochemisty and immunohistochemistry.Results:Compared with sham operation group,increase in body weight in model group was obviously lowered;liver weight,spleen weight,liver/body ratio and spleen/body ratio increased at first stage,then decreased at late stage;serum Alb content decreased continuously,while TP increased first and then decreased later;serum ALT and AST activity peaked after 3d of ligation,then valleyed at 2W of ligation and maintain a low level from 3W of ligation,but still being higher than that in sham operation group;serum GGT activity and TBil content increased continuously,while ALP activity peaked at 2W of modeling,then decreased and maintained at a low level;Hyp content in liver tissue increased continuously;bile duct proliferation in periportal area was seen from 3d of ligation,this proliferation continued from 1W to 3W of modeling,and proliferated cholangiocytes formed small bile duct,and at the same time,differentiation was seen in hepatocytes.Proliferated small bile duct,fibroblast and collagen formed septa reconstructed lobule to form pseusolobule.Normal hepatocytes were rarely seen in rats liver tissue at 4W and 5W of modeling.CK-19 expression showed that cholangiocytes proliferated from 3d of modeling and continuously increased with 2W,while this proliferation decreased from 3W of modeling.Conclusion:The main pathological changes in rat cholestatic cirrhosis are cholestasis,cholangiocytes proliferation,decrease in hepatocytes number,new proliferated cholangiocytes related deposition of collagen;serum ALT and AST activity increases first and then decreases later,No definite correlation is seen between spleen weight and cirrhosis;decreases in hepatocytes number is not only attributed to apoptosis and necrosis,but also to differentiation like changes." @default.
- W2352982425 created "2016-06-24" @default.
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- W2352982425 date "2006-01-01" @default.
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- W2352982425 title "Dynamic changes of cholestatic cirrhosis in rats and its significance" @default.
- W2352982425 hasPublicationYear "2006" @default.
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