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- W2352983165 abstract "Objective To find a suitable way to deliver macromolecular biological proteins into the brain via pathway.Methods The Kunming rats were divided into two groups.One group were given pSSHG/NT4-GFP-Ant AAV at a dose of 10μl per day of each nostril by intranasal administration.The other group were given pSSHG/GFP AAV in the same way.The rats were killed after ten days and frozen slides were made,and then were detected by laser confocal microscope.Results The fluorescence can be observed at the membrana mucosa nasi,olfactory bulb and hippocampus in the group which was given pSSHG/NT4-GFP-Ant by intranasal administration.By contrast,the fluorescence can be observed only at the membrana mucosa nasi in the group which was given pSSHG/GFP.Conclusion The animal experiment confirmed that macromolecular protein modified by cell penetrating peptides can be delivered into brain via nose-brain pathway." @default.
- W2352983165 created "2016-06-24" @default.
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- W2352983165 date "2010-01-01" @default.
- W2352983165 modified "2023-09-24" @default.
- W2352983165 title "The delivery of macromolecular proteins to the brain via nose-brain pathway by expressive NT4-GFP-Ant recombinant gene in vivo" @default.
- W2352983165 hasPublicationYear "2010" @default.
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