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- W2353004537 abstract "Objective: To investigate the changes of serum interleukin-6(IL-6) induced by chronic constriction injury(CCI) of sciatic nerve,and to determine the role of IL-6 in the development of neuropathic pain.MethodS: Thirty-six male healthy Wistar rats weighting 250 to 300 g were anesthetized with sodium barbiturate.Unilateral sciatic nerve was exposed and ligated in the middle of leg in 12 rats in experiment group.Four ligatures were loosely tied around the sciatic nerve,and the distances between the nerve and the ligatures were about 1 mm.The sciatic nerve in the contralateral thigh was exposed and mobilized but not ligated.The thermal nociceptive threshold was determined by measuring the withdrawal latency of hind paw placed on a radiate heat source 3,5,7,9,11,13,and 15 days after surgery.The rats were killed 15 days after surgery.Serum was frozen in liquid nitrogen for determining the content of IL-6.The percentage of paw withdrawal latency was determined.Results: The average baseline of nociceptive threshold(withdrawal latency) was(18.25±(2.02))s.There was significant difference in paw withdrawal latency between the hind paws 3,5,7,9,11,13,and 15 days after surgery.The serum content of IL-6 increased 15 days after surgery.Conclusion: The serum content of IL-6 is ralated to the development of neuropathic pain." @default.
- W2353004537 created "2016-06-24" @default.
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- W2353004537 date "2005-01-01" @default.
- W2353004537 modified "2023-09-26" @default.
- W2353004537 title "Changes and relationships of pain threshold and serum IL-6 in rats with sciatic nerve injury induced by chronic constriction" @default.
- W2353004537 hasPublicationYear "2005" @default.
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