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- W2353013459 abstract "AIM: To prepare flexible nanoliposomes made from active ingredients,phillyrin and volatile oil,from forsythia suspense and study their transdermal delivery system.METHODS: Flexible nanolipsomes of phill-yrin(WN group) and phillyrin in combination with forsythia volatile oil(OWN group) were prepared by the meth-od of membrane-dispersion.Its appearance and particle sizes were measured.Transdermal experiments were carried out on the modified Franz diffusion pool through in vitro mouse skin.HPLC was applied to determining the phillyrin content to compare transdermal rate and cumulative permeation amount of various flexible nanoliposomes.RESULTS: The particle size of the WN group was(180.7 ± 13.69)nm,the Zata potential was-48.8 mV,the average encapsulation percentage was(82.53 ± 2.68)%;the particle size of the OWN group was(212.3 ± 15.31)nm,Zata potential was-51.2 mV,the average encapsulation percentage was(70.49 ± 1.06)%.The accu-mulated permeation amount of the OWN group in 8 hours was(291.92 ± 23.22) μg/cm2,its transdermal permea-bility in 8 hours was 36.49 μg/(cm2.h),which was 6.10 folds that of the WS group and 1.92 folds that of the WN group.This difference had statistical significance(P 0.01).CONCLUSION: Flexible nanoliposomes can significantly speed up the drug's permeation rate of entering the skin,and the addition of volatile oil of forsythia sus-pensa promote the transdermal delivery." @default.
- W2353013459 created "2016-06-24" @default.
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- W2353013459 date "2010-01-01" @default.
- W2353013459 modified "2023-09-28" @default.
- W2353013459 title "Transdermal absorption of flexible nanoliposomes of different active ingredients of forsythia suspensa" @default.
- W2353013459 hasPublicationYear "2010" @default.
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