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- W2353014503 abstract "Objective To study the protective effects of platycodon grandiflorum extractive on mice fulminant liver failure induced by D-GalN/LPS.Methods The mouse model of fulminant liver failure was established by administering D-GalN/LPS.Mice in experimental group were given either lower dose of platycodon grandiflorum extractive(150 mg/kg),or higher dose(300 mg/kg),and the mice in positive control group were given NAC with a dose of 300 mg/kg.All mice were administered medication twice followed by abdominal injection of D-GalN/LPS.After 8h,mice carotid artery blood was taken,and serum AST as well as ALT levels were detected.Mice livers were also taken and keep in liquid nitrogen.Results Mice in model group showed serious liver damage.The serum levels of AST and ALT were significantly decreased in mice administered with platycodon grandiflorum extractive compared with those of model group.Conclusion Platycodon grandiflorum extractive could protect liver by lessening fulminant hepatic damage induced by D-GalN/LPS." @default.
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- W2353014503 date "2008-01-01" @default.
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- W2353014503 title "Protective effects of platycodon grandiflorum extractive on fulminant liver failure induced by D-GalN/LPS in mice" @default.
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