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- W2353026635 abstract "Objective To evaluate cerebral autoregulation in cerebral vascular disease using transeranial Doppler(TCD)-CO_2 test and head-upright tilt test(HUTT).Methods Thirty-two patients with occlusive cerebral vascular disease (group A),28 cerebral infarction patients without stenosis (group B), and 26 controls were included.Cerebrovascular reactivity was calculated in terms of the breath-holding index (BHI) and vascular motor reactivity (VMR) by TCD-CO_2 test.Changes of cerebral blood flow velocity (CBFV),blood pressure (BP) and heart rate (HR) were detected during HUTT to assess the cerebral pressure-autoregulation.Results Compared with controls,VMR decreased in group A and B,being 0.18±0.02,0.26±0.04 respectively,and so did BHI,being 0.76±0.15,1.05±0.15 respectively with significance(P0.05).In group A,ipsilateral and contralateral VMR decreased significantly to 0.10± 0.01,0.22±0.02 respectively and BHI to 0.51±0.14,0.94±0.16 respectively.Ipsilateral BHI was less than 0.69 (P=0.013).Decreased BHI was related to cerebral infarction (B=2.234,P=0.016,Logistic regression analysis).BP and HR increased,while CBFV decreased during tilt position.BP and CBFV decreased during tilt in the 3 cases of orthostatic hypotension(P0.05).Pearson analysis showed a linkage between BP and CBFV changes (r=0.430,P=0.004).Conclusions Cerebrovascular reactivity is impaired in occlusive cerebral vascular disease and cerebral infarction,especially in the ipsilateral to the stenosis.It may increase the risk of cerebral infarction.BP and HR,elevating mildly in upright position, participate in the cerebral autoregulation." @default.
- W2353026635 created "2016-06-24" @default.
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- W2353026635 date "2007-01-01" @default.
- W2353026635 modified "2023-09-23" @default.
- W2353026635 title "Cerebral autoregulation in cerebral vascular disease" @default.
- W2353026635 hasPublicationYear "2007" @default.
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