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- W2353032492 abstract "Objective This study is to investigate the regulations of the functional changes of body injury response syndrome (BIRS) under the influence of the pathogenesis.Methods (1) In the experiment I, 36 healthy dogs were randomly divided into 6 groups and abdominal aortas of each group had been clamped respectively for 0, 15, 25, 35, 45 and 60minutes; the data of hemodynamics, blood acid|base and plasma electrolytes, coagulation state were collected and analyzed for the functions changes of multisystems after injury. (2)In the experiment II, cardiac output, total peripheral resistance, right carotid and femoral arterial flow of 6 dogs were measured for analysis of the functional changes of hemodynamics of the circulation systems. (3) In the experiment III, the tissues of kidney, liver, pancreas and intestine from 3 dogs in each group of the experiment I and tissues of brain, spinal and lung from other 18 dogs (also divided into 6 groups) were obtained and analyzed for the structural changes of multisystems after injury by electronic microscopy. (4) In the experiment IV, 30 healthy dogs were randomly divided into 5 groups which were with or without abdominal aorta clamping or with pharmaceutical or snake venom stimuli, the functional{ }changes of the central or peripheral nerve system after injury were analyzed by measuring action potential of diaphragmatic nerve and muscle synchronously. (5) In the experiment V, the functional changes of EEG, ECG and action potential of respiration were measured synchronously for analysis of the functional changes of central nerve system. Results The method of the abdominal aorta clamping could lead to body injury response syndrome (BIRS) and this experimental method was in fact the experimental model of BIRS.Conclusion BIRS is a kind of multisystem time|space theory (also called general life time|space|field theory) and reevaluates the contemporary pathophysiology and is a great unified view for the changes of pahtophysiologic process in the total diseases and syndromes." @default.
- W2353032492 created "2016-06-24" @default.
- W2353032492 creator A5073378476 @default.
- W2353032492 date "2002-01-01" @default.
- W2353032492 modified "2023-09-25" @default.
- W2353032492 title "The prospective experimental study on body injury response syndrome (I. Investigation of the time-space-field changes of multisystem functions) --Revaluation on the contemporary pathophysiology by applying multisystem time-space theory" @default.
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