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- W2353041309 abstract "【Objective】To explore the relationship between serum IP-4 levels and the disease activity,and the role of IP-4 in the pathogenesis of SLE. 【Methods】Sera were collected from 120 patients with SLE, 46 healthy controls and 36 patients with RA. Serum IP-4 levels were measured by ELISA, hs-CRP was measured through par-ticle enhanced immunoturbidemetric method by using analysis instrument CX9. 【Results】 IP-4 levels in active groups (403.7±234.2) μg/L were markedly higher than those in inactive groups (267.6±69.7) μg/L and controls (102.1±32.1) μg/L (P 0.001). The levels of IP-4 in the active lupus nephritis (465.7±244.2) μg/L were significantly higher than in active no-renal involvement group (297.6±99.7) μg/L and controls (P 0.001). In addition, the levels of IP-4 were markedly increased in the SLE patients depending on the disease activity. Serum IP-4 levels correlated significantly with the overall SLEDAI scoreγ=0. 6451 (P 0.001). as well as the renal SLEDAI score γ=0.6951, (P 0.001). 【Conclusions】IP-4 may play role in the pathogenesis of SLE, especially in the patients with lupus nephri-tis. Serum IP-4 levels correlated significantly with the activity of SLE. It suggested that serum IP-4 levels could be a good indicator in SLE with renal involvement." @default.
- W2353041309 created "2016-06-24" @default.
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- W2353041309 date "2008-01-01" @default.
- W2353041309 modified "2023-09-25" @default.
- W2353041309 title "Serum levels of IFN-inducible protein-4 related to the activity of systemic lupus erythematosus" @default.
- W2353041309 hasPublicationYear "2008" @default.
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