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- W2353048130 abstract "AIM To study the antitumor effect of Yulangsan polysaccharide(YLSPS) on sarcoma 180 in vivo,and to evaluate the synergetic effect and attenuated toxic effect of YLSPS in combination with cyclophosphamide(CTX) .METHODS Kunming mice were injected subcutaneously with S180 cancer cells to investigate the effects of different concentration of YLSPS(0.15,0.30,and 0.60 g·kg-1·d-1) on thymus index(TI),spleen index(SI),cancer weight and the rates of tumor inhibition.SOD and MDA in liver were detected.The effects of YLSPS(0.15,0.30,and 0.60 g·kg-1·d-1) alone with combination of CTX(0.01 g·kg-1· d-1) on tumor weight were compared,the effects of the drug combination on TI,SI and WBC of mice were also tested.RESULTS TI and SI in YLSPS(0.15,0.30,and 0.60 g·kg-1·d-1) groups were(31 ± s 7),(35 ± 6),(37 ± 6) mg·g-1,and(92 ± 16),(93 ± 8),(106 ± 8) mg·g-1,respectively.TI and SI in YLSPS(0.30 and 0.60 g·kg-1·d-1) groups were significantly increased compared with those in the model group(P 0.01) .Tumor growth was apparently inhibited by YLSPS(0.15,0.30,and 0.60 g·kg-1·d-1) with the inhibitory ratio of 39.7%,41.3%,and 52.6%,respectively.The activity of SOD was increased and the production of MDA was decreased by YLSPS.In combination with YLSPS(0.15,0.30,and 0.60 g·kg-1·d-1) and CTX(0.01 g·kg-1·d-1),q values were all from 0.85 to 1.25.TI,SI,and the blood leukocyte count,which were decreased by CTX(0.01 g·kg-1·d-1),were ameliorated remarkably.CONCLUSION YLSPS has potent inhibitory effect on the growth of implanted S180 in mice and has synergetic effect and attenuated toxic effect in combination with CTX." @default.
- W2353048130 created "2016-06-24" @default.
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- W2353048130 date "2010-01-01" @default.
- W2353048130 modified "2023-09-23" @default.
- W2353048130 title "Antitumor effect of Yulangsan polysaccharides in vivo" @default.
- W2353048130 hasPublicationYear "2010" @default.
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