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- W2353075885 abstract "Objective To investigate the correlation between serum 8-hydroxy-guanine(8-OHdG) and insulin resistance (IR) and intima-media thickness(IMT) of the carotid artery in patients with type 2 diabetes mellitus(T2DM).Methods The concentrations of fasting blood glucose(FBG),blood lipid,insulin(Ins),glycolated hemoglobin(HbA1c) and serum 8-OHdG were measured and body mas index and insulin resistance index(Homa-IR) were calculated in 25 healthy subjects(group C) and 50 T2DM patients,who were divided into groups of A(32 cases,IMT1.0 mm) and B(18 cases,IMT≥1.0 mm or having atheromatous plaque).Results Serum 8-OHdG was significantly higher in groups of A and B than that in group C,which was significantly higher in group B than that in group C(P0.05).Serum 8-OHdG level was positively correlated with Homa-IR and IMT.Stepwise multiple regression analysis showed that 8-OHdG level,Homa-IR,HbA1c and TC were the risk factors for IMT.Conclusion The increased level of serum 8-OHdG is correlated with insulin resistance and increased IMT of the carotid artery,indicating that oxidative stress participates in the formation of insulin resistance and occurrence of diabetic complications." @default.
- W2353075885 created "2016-06-24" @default.
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- W2353075885 date "2011-01-01" @default.
- W2353075885 modified "2023-09-26" @default.
- W2353075885 title "Correlation of serum 8-OHdG with insulin resistance and intima-media thickness of the carotid artery in type 2 diabetic patients" @default.
- W2353075885 hasPublicationYear "2011" @default.
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