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- W2353093849 abstract "Objective To study the expression and distribution of TMP activity in the dorsal raphe nucleus of PTSD(posttraumatic stress disorder) rats.Methods The SPS-method was used to set up the rat PTSD models.Rats were randomly divided into 1d,7d and 14d groups of SPS and the normal group.The changes of TMP activity and distribution of TMP in the dorsal raphe nucleus was detected by light microscopy and transmission electron microscopy(TEM).Results TMP was widely distributed throughout the dorsal raphe nucleus region,mainly in the cytoplasm,appearing as buffy particles.Positive expression of TMP,highly electron-dense black granules,was located in lysosomes of all groups.Evaluation of TMP by enzymohistochemistry indicated a significant increase in the SPS model groups compared with the normal control group(P0.05),which peaked in the SPS 7d group(P0.05).Conclusion The expression of TMP significantly increases after SPS stimulation in the dorsal raphe neurons of PTSD rats,which may indicate that TMP is involved in degradation and processing of the apoptotic products in the dorsal raphe nucleus." @default.
- W2353093849 created "2016-06-24" @default.
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- W2353093849 date "2012-01-01" @default.
- W2353093849 modified "2023-09-23" @default.
- W2353093849 title "Experimental study on changes of TMP activity in dorsal raphe nucleus neurons of PTSD rats by light and electron microscopy" @default.
- W2353093849 hasPublicationYear "2012" @default.
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