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- W2353106474 abstract "Objective:To investigate the expression of C-X-C chemokine receptor type 7(CXCR7)which is the receptor of stromal cell-derived factor-1(SDF-1)in alkali burned corneal tissues in mice,and to explore whether CXCR7is involved in corneal neovascularization(CNV)induced by alkali burn.Methods:Alkali burn-induced CNV animal model was constructed in BALB/c mice by placing the filter paper with NaOH to the nasal-side cornea for 40 seconds.The expressions of stromal-derived factor 1(SDF-1),CXCR4,CXCR7 and vascular endothelial growth factor(VEGF)were detected by real-time PCR and western blotting at 3,7,14 days after alkali burning.In addition,immunofluorescence staining was used for protein expression of CXCR7 at 14 days after alkali burning.Results:The neovascular area was consecutively developed within14 days after alkali burning.Real-time PCR results showed that the mRNA expression levels of SDF-1,CXCR4,CXCR7 and VEGF were significantly increased at 3,7,14 days after alkali burning in corneal tissues of mice as compared with the normal control group(P 0.05).Western blotting results showed that the protein expression levels of SDF-1,CXCR4,CXCR7 and VEGF were significantly increased at 7 days and 14 days after alkali burning as compared with the normal control group(P0.05).However,there was no statistical difference in their levels between7 days and 14 days after alkali burning.The immunofluorescence staining showed that CXCR7 protein was weakly positively expressed in corneal epithelium of normal mice,whereas the expression of CXCR7 protein was significantly increased at 14 days after alkali burning in corneal epithelial cell layer,stromal layer and new blood vessels.Conclusions:The expression of CXCR7 after alkali burning is significant in corneal tissues of mice,indicating that it may play an important role in alkali burn-induced CNV." @default.
- W2353106474 created "2016-06-24" @default.
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- W2353106474 date "2013-01-01" @default.
- W2353106474 modified "2023-09-23" @default.
- W2353106474 title "Expression of C-X-C Chemokine Receptor Type 4in Alkali Burned Corneal Tissues in Mice" @default.
- W2353106474 hasPublicationYear "2013" @default.
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