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- W2353115068 abstract "Objective To evaluate the efficacy and safety of 48 weeks adefovir dipivoxil(ADV),endecavir treatment for patients with active cirrhosis.Methods 60 patients with active cirrhosis were randomly divided into two groups.An adefovir dipivoxil(ADV)group:30 patients treated with 10 mg of ADV a day;and an endecavir(ETV)group:30 patiens treated with 0.5mg of ETV a day.The course of treatment lasted 48 weeks.Serum levels of alanine amino transferase(ALT),aspartate amino transferase(AST),ALB,TBiL,HBeAg,HBV DNA,PCIII,IVC,LN,and HA,renal function and drug adverse reactions during the treatment of the two groups were checked,compared and analyzed.Result The ratios of recovery for fiver functions and the negativity rate of HBV DNA,HBeAg,included sero-conversion rate of HBeAg/HBeAb,were increased with prolongation of the treatment period;However the differences between the two groups were not significant.Two groups were not suffered from virus variation.No drug related renal function impairment was found during the treatment.Two patients of each group had adverse drug reactions but both were mild.Conclusion The efficacy and safety of adefovir dipivoxil and endecavir treatment for the above patients were similar,but the ratio of negativity rate of HBV DNA is lower in the ETV treatment group." @default.
- W2353115068 created "2016-06-24" @default.
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- W2353115068 date "2008-01-01" @default.
- W2353115068 modified "2023-09-23" @default.
- W2353115068 title "A Clinical Study of Adefovir Dipivoxil,Endecavir Treatment for Patients with Active Cirrhosis" @default.
- W2353115068 hasPublicationYear "2008" @default.
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