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- W2353124908 abstract "OBJECTIVE To revalue the determination method for related substances in cimetidine.METHODS The related substances in cimetidine were tested by TLC and HPLC,respectively.The HPLC method was carried out on a C18 column with the mixture of methanol-water(240:760)(dissolved 0.3 mL of phosphoric acid and 0.94 g sodium hexanesulfonate in 1 000 mL methanol) as mobile phase and UV wavelength at 220 nm.RESULTS The results of related substances tested by TLC were all within 0.5% in 8 batches of cimetidine from 7 manufacturers,but only one batch was within 0.5% by HPLC.CONCLUSION The result of related substances in cimetidine tested by HPLC was more credible than the result tested by TLC." @default.
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- W2353124908 date "2010-01-01" @default.
- W2353124908 modified "2023-09-24" @default.
- W2353124908 title "Revaluation of the Determination Method for Related Substances in Cimetidine" @default.
- W2353124908 hasPublicationYear "2010" @default.
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