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- W2353140147 abstract "Objective To observe the expression of TnC gene in development of normal palate shelf and the formation of cleft palate of mice.It is aimed to explore the relation between TnC gene and the formation of cleft palate.Methods The TnC expression in embyonic palatine process tissues in the experimental group induced by retinoic acid and control groups was detected by real-time PCR from GD11～GD16 and in situ hybridization at GD13 and GD14.Results TnC was expressed in all normal and cleft palates at GD11～GD16.To the normal palates,the highest expression was in GD16,which was significant differences to the other time samples.There was no difference of abundance among all the samples of the cleft palates.The TnC expression in normal palates was stronger than that in the cleft palates during GD11-GD16.TnC expression was detected in both the epithelium and mesenchyme of the anterior region of normal developing palatal shelves at GD13 and GD14,the TnC expression was detected in the the epithelium,but was down regulated in mesenchyme of GD13 palatal shelf.TnC was expression in the normal posterior palate at GD14,but was lower than its of anterior region.TnC was absent in both the epithelium and mesenchyme of the anterior region of cleft palatal at GD14.Conclusion TnC gene played an important role in development of palate shelf of mice.The down expression of TnC gene was related to the occurrence of cleft palate." @default.
- W2353140147 created "2016-06-24" @default.
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- W2353140147 date "2008-01-01" @default.
- W2353140147 modified "2023-09-25" @default.
- W2353140147 title "Effects of TnC gene on development of normal palate shelf and the formation of cleft palate in mice" @default.
- W2353140147 hasPublicationYear "2008" @default.
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