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- W2353172393 abstract "Objective To investigate the patterns of peripheral blood lymphocytes immunolophenotype in polymyositis(PM) and the correlations with clinical findings. Methods The percentage of CD3+, CD4+, CD8+, CD28+, CD8+/CD28+, CD45RA+, CD4+/CD45RA+, CD4+/CD29+, CD19+, CD5+/CD19+, CD56+, HLA-DR+, CD3+/HLA-DR+, CD69+ were measured by flow cytometry from 23 PM patients and 18 age, sex matched healthy controls. Results Compared with the controls, the percentages of CD8+ and CD8+/CD28+ lymphocytes were decreased, the percentage of CD3+/HLA-DR+ lymphocytes were elevated in patients with PM(P0.05) while CD3+, CD4+, CD28+, CD45RA+, CD4+/CD45RA+, CD4+/CD29+, CD19+, CD5+/CD19+, CD56+, HLA-DR+, CD69+ were not significantly different from those of the controls. The percentages of CD8+ and CD8+/CD28+ in the patients with disease course ≤ 2 months were lower than those2 months. There were no significant correlations between the levels of immunolophenotype and clinical, laboratory findings(P0.05). Conclusion CD8+ lymphocytes, especially the CD8+/CD28+ lymphocytes play a role in the pathogenesis of polymyositis." @default.
- W2353172393 created "2016-06-24" @default.
- W2353172393 creator A5055021102 @default.
- W2353172393 date "2004-01-01" @default.
- W2353172393 modified "2023-09-22" @default.
- W2353172393 title "Detection of peripheral blood lymphocytes immunophenotype in patients with polymyositis" @default.
- W2353172393 hasPublicationYear "2004" @default.
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