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- W2353179936 abstract "Objective To explore the mechanisms of curcumin in treating nephrotic syndrome by observing the alteration of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and nephrin in renal tissue of rats with adriamycin (ADR)-induced nephrosis. Methods Nephrosis was induced by single intravenous injection of ADR (5 mg/kg). Fifty Sprague-Dawley rats were randomly divided into five groups: control group,nephrosis model group,nephrosis rats treated with low-dose and high-dose curcumin,and nephrosis rats treated with glucocorticoid. The 24-hour urine was collected 28 days after ADR injection to measure 24-hour urinary protein,and all rats were sacrificed 29 days after ADR injection. The levels of malondialdehyde (MDA) and the activeity of superoxide dismutase (SOD) in renal tissue were determined by chemiluminescence assay,and the mRNA and protein expression of NADPH oxidase p47phox and nephrin in renal tissue were determined by real time polymerase chain reaction and western blotting. Results The levels of urinary protein increased significantly in ADR-induced nephrosis group compared to control group; the treatment of curcumin could reduced markedly urinary protein compared to ADR-induced neprhosis group. Compared with control group,ADR-induced nephrosis group showed an elevation in MDA levels and a reduction in SOD activity in renal tissue. Treatment of curcumin markedly decreased the levels of MDA and increased the activity of SOD compared to ADR-induced nephrosis group. Compared with control group,the mRNA and protein expression of p47phox in ADR-induced nephrosis groups were significantly increased.Treatment of curummin significantly decreased the expression of p47phox in renal tissue compared to ADR-induced nephrosis group. Compared with control group,the mRNA and protein expression of nephrin in ADR-induced nephrosis were significantly reduced. Treatment of curummin significantly increased the expression of nephrin compared to ADR-induced nephrosis group. Conclusion Curcumin reduced excretion of urine protein in response to adriamycin via downregulation of p47phox expression and upregulation of nephrin expression. Thereby,curcumin may protect against ADR-induced nephrosis." @default.
- W2353179936 created "2016-06-24" @default.
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- W2353179936 date "2013-01-01" @default.
- W2353179936 modified "2023-09-28" @default.
- W2353179936 title "Effect of Curcumin on Expression of NAPDH Ofxidase and Nephrin in the Renal Tissue of Rats with Adriamycin-induced Nephrosis" @default.
- W2353179936 hasPublicationYear "2013" @default.
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