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- W2353203795 abstract "Objective To study the immunoregulatory mechanisms of responsiveness and nonresponsiveness to hepatitis B vaccine (HBVac) by analyzing the changes of IL2/IL2R system and IL10 in children who had intrauterine hepatitis B virus (HBV) infection Methods Fortyseven subjects, including 13 children who had intrauterine HBV infection and were not responsive to HBVac (nonresponders), 13 children who had intrauterine HBV infection and were responsive to HBVac (responders) and 21 healthy children who were immunized against HBV (normal control)Peripheral blood mononuclear cells (PBMC) taken from the subjects were cultured in vitro and PBMC mIL2R was determined by using flow cytometry; IL2, sIL2R and IL10 contents were determined by using sandwich enzyme immunoassay Results After specific stimulation with HBsAg, the expression levels of mIL2R of the 3 groups showed significant difference, the lowest level was seen in nonresponder group and the highest in normal control group The level of sIL2R of the nonresponder group was lower than those of responders and normal control group; this difference was statistically highly significant The level of IL2 production of the nonresponder group was low While only the responder group had increased production of IL10 after exogenous stimulation Conclusion Low level of IL2 production and IL2R expression after the HBsAg stimulation may contribute to immunization failure in children with intrauterine HBV infection ;there may be an immune tolerance mechanism In responders who had intrauterine HBV infection, production of HBsAgspecific antibodies may be related to the elevated level of IL10" @default.
- W2353203795 created "2016-06-24" @default.
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- W2353203795 date "1999-01-01" @default.
- W2353203795 modified "2023-09-22" @default.
- W2353203795 title "A study on the relationship between cytokines and failure of immunization with hepatitis B vaccine in children who had intrauterine HBV infection" @default.
- W2353203795 hasPublicationYear "1999" @default.
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