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- W2353204395 abstract "ObjectiveTo observe the changes of behavior from infancy to agedness Sprague Dawley rats, and correlate age-increasing with learning and memory ability. Methods84 male Sprague Dawley rats were studied: aged 1 month (n=16), 3 months (n=16), 6 months (n=20), 18 months (n=19), and 24 months (n=13). The rats were put through the Morris water maze test and the straight-channel maze test. ResultsRats showed increasing improvement in the water maze test from 1 month to 6 months of age; 6-month-old rats had the shortest escape latency time and shortest swim distance, as well as the least number of errors in encountering blind ends. After 6 months of age performance began to deteriorate progressively, declining to that of a one-month-old rat at 24 months of age. ConclusionLearning and memory ability of rats shows increasing improvement from birth, reaching a peak at 6 months of age; from then it begins to suffer progressive deterioration, declining to that of a one-month-old rat at 24 months of age. Changes in the above-mentioned ability may be related to hippocampal synaptic development." @default.
- W2353204395 created "2016-06-24" @default.
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- W2353204395 date "2006-01-01" @default.
- W2353204395 modified "2023-09-23" @default.
- W2353204395 title "Research experiments on the behavior changes of aging rats" @default.
- W2353204395 hasPublicationYear "2006" @default.
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