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- W2353204661 abstract "Objective:To investigate the impact on the expression of Caspase-3 and myocardia apoptosis of intrathymic injection of anti-fas monoclonal antibody on reject reaction after rat heart transplantation. Method:Using rat allograft heterotopic heart transplantation models,Wistar rat hearts were transplanted to SD rats and randomly divided into three groups.Study group: (intrathymic injection of anti-fas monoclonal antibody 0.1 mg/kg once and abdominal injection of NS 2 mL o.d.); CsA group(intrathymic injection of PBS 1 mL once and abdominal injection of CsA 8 mg/kg o.d. )Control group: (intrathymic injection of PBS 1 mL once and abdominal injection of NS 2 mL o.d.). Animals were given above drugs one days before operations after operation. Myocardial pathological damage and rejection grade were measured, the express of Caspase-3 mRNA were measured by RT-PCR and the active Caspase-3 protein by immunohistochemistry and apoptosis by TUNEL. Result:1.Rejection grade of Study group 2.13±0.64 were lower than control group 3.75±0.46 (P0.05), and higher than CsA group 1.25±0.68(P0.05). 2.Expression of Caspase-3 mRNA on the transplanted heart were lower in study group 0.62±0.05 than control group 0.87±0.12(P0.05),and higher than CsA group 0.59±0.08(P0.05). 3.The expression of active Caspase-3 protein were lower in study group 113±12.5 than control group 223±4.80 (P0.05),and higher than CsA group 95±4.50 (P0.05). 4.The AI were lower in study group 7.32±0.58 than the control group 11.07±1.18 (P0.05),and higher than CsA group 5.67±0.43 (P0.05).Conclusion:Recipient intrathymic injection of anti-Fas monoclonal antibody can lessen the rejection grade after heart transplantation and reduce expression of Caspase-3 mRNA and active Caspase-3 protein, cardiomyocyte apoptosis in the experimental transplanted heart." @default.
- W2353204661 created "2016-06-24" @default.
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- W2353204661 date "2008-01-01" @default.
- W2353204661 modified "2023-09-27" @default.
- W2353204661 title "Effect and mechanism of recipient intrathymic injection of anti-Fas monoclonal antibody on reject reaction after heart transplantation" @default.
- W2353204661 hasPublicationYear "2008" @default.
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