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- W2353224663 abstract "Objective To explore the pathogenesis of alopecia areata(AA) by determining the level of CD4+CD25+Treg cells and transforming growth factor-β1(TGF-β1) in peripheral blood from patients with AA.Methods The proportion of peripheral blood CD4+ CD25+ Treg in T lymphocyte subgroups and the content of TGF-β1 were determined by flow cytometry and ELISA respectively in 50 AA patients without therapy,compared with 30 controls.Results The proportion of CD4+CD25+Treg in T lymphocytes and level of TGF-β1 in patients serum with AA were lower than those in control(P0.01),and the severe group were significantly lower than those in the control group and local AA(P0.01),the local AA were lower than those in the control group(P0.05).The correlation of CD4+CD25+Treg(r=-0.566,P0.01) and TGF-β1(r=-0.471,P0.01) with SALT were negative in patients.There were significant positive correlation between CD4+CD25+Treg and TGF-β1(r=0.584,P0.01).Conclusion The proportion of CD4+CD25+Treg cells and the concentration of TGF-β1 in blood serum in patients with AA are declined obviously,which indicated that two factors are the mechanism of immune balance in patients with AA." @default.
- W2353224663 created "2016-06-24" @default.
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- W2353224663 date "2012-01-01" @default.
- W2353224663 modified "2023-09-28" @default.
- W2353224663 title "The Detection of CD4~+ CD25~+ Regulatory T Cell and TGF-β_1 in Peripheral Blood from Patients with Alopecia Areata" @default.
- W2353224663 hasPublicationYear "2012" @default.
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