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- W2353247273 abstract "Aim:To investigate the effect of insulin on the HO-CO-cGMP system.Methods:①Isolated wistar rat aortas were cultured in the media containing different concentration insulin (0.04 mU/L,0.08 mU/L,0.16 mU/L) for 24 hours.The relative activity of HO was measured with the bilirubin (pmol/g/h).②The wistar rat aortic smooth muscle cells were cultured in the solution containing insulin (consistency same above) for 24 hours.The relative amounts of carbon monoxide released into the media were measured with the quantifying carbon monoxide hemoglobin (COHb).③Isolated rat aortas were cultured in the media containing different concentration insulin (consistency same above) for 24 hours.The cGMP content in the tissue of aorta were measured by radioimmunitic method.Resultes:In the condition of insulin presenced in the solution (consistency as above:0.04 mU/L,0.08 mU/L and 0.16 mU/L):①The HO activities in the aorta were increased to 48.2%,60.8% and 80.7%,respectively (vs control, P 0.01).②The COHb in the culture solution of VSMCs were increased to 8.7%,17.4%,39.1%,respectively(vs control, P 0.05 or P 0.01).③The cGMP content in the tissue of aortas were increased to 96.6%,197.1% and 130.7% respectively (vs control P 0.01).Conclusion:This study suggests that the insulin may activate the HO-CO-cGMP system in Wistar rat aorta.This may be one of the mechanisms by which insulin causes vasodilation." @default.
- W2353247273 created "2016-06-24" @default.
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- W2353247273 date "2000-01-01" @default.
- W2353247273 modified "2023-09-23" @default.
- W2353247273 title "EFFECT OF INSULIN ON HEME OXYGENASE-CARBON MONOXIDE-CYCLIC GUANOSINEMONOPHOSPHATE SYSTEM IN RAT AORTA" @default.
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