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- W2353249455 abstract "Levodopa and dopamine receptor agonists are the main therapeutic drugs currently used for Parkinson's disease (PD). However recently in vitro and in vivo studies have revealed that levodopa may be neurotoxic to dopamine neuron, while dopamine receptor agonists may have neuroprotective effect against neuronal injury in the nigro-striatal system. This neuroprotective effect of dopamine receptor agonists may resulted from the mechanism through their properties concerning about the antioxidation, neurotrophic stimulation, antiapoptosis and mitochondrial membrane potential stabilization. This paper retrospectively present the evidences and mechanisms of neuroprotection provided by several dopamine receptor agonists, such as apomorphine, pramipexole and ropinirole, and suggests that these drugs may be able to slow down the progression of the disease in addition to their symptomatic relief of PD." @default.
- W2353249455 created "2016-06-24" @default.
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- W2353249455 date "2005-01-01" @default.
- W2353249455 modified "2023-09-23" @default.
- W2353249455 title "Neuroprotective effect of dopamine receptor agonists" @default.
- W2353249455 hasPublicationYear "2005" @default.
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