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- W2353257680 abstract "Objective To observe the protective effect of Ulinastatin in rat islet isolation and advance an improved method in rat pancreas islet isolation.Methods Rat pancreas was perfused with Hanks solution containing collagenase. The rats were divided into 3 group according the Ulinastatin concentrations in collagense: low-concentration Ulinastatin ( 2500 U/ml) group, high-concentration Ulinastatin ( 5000 U/ml) and control group (no Ulinastatin). The isolated pancreases were compared among the groups. Results The shape and number of the isolated pancreases in low-concentration Ulinastatin and high-concentration Ulinastatin groups were superior to those in control group (P 0.01). Under the stimuli of no glucose, low glucose, high glucose and theophylline with high glucose, the amount of insulin release in low-concentration Ulinastatin and high-concentration Ulinastatin groups was greater than in control group (P 0.01). Conclusion Ulinastatin perfusion can protect the islet from trypsin digestion in the process of rat islet separation." @default.
- W2353257680 created "2016-06-24" @default.
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- W2353257680 date "2005-01-01" @default.
- W2353257680 modified "2023-09-23" @default.
- W2353257680 title "Protective effect of Ulinastatin in rat islet isolation" @default.
- W2353257680 hasPublicationYear "2005" @default.
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