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- W2353259780 abstract "Objective To investigate the hemodynamics and level of tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6) in dogs after resuscitation from cardiac arrest. Methods Ventricular fibrillation (VF) was induced by dogs resuscitated external electricity and applied for 3 minutes.Twelve dogs were randomly divided into normal group (n=6) and CPR group(n=6). Cardiac output(CO) and pulmonary artery wedge pressure (PAWP) were measured and blood samples were collected in 12 dogs before and at 6 hours after successful resuscitation. Serum concentration of TNF-α and IL-6 were determined by radioimmunoassay(RIA).Myocardial tissue was taken out for RT-PCR 6 hours after CPR. Results The hemodynamic parameters weren't significantly different before cardiac arrest in the two groups. The MAP of CPR group was higher than that of normal group at return of spontaneous circulation(ROSC), and MAP was lower than that of normal group at 4 hours and 6 hours after resuscitation. These parameters of CPR group were lower than those in normal group after successful resuscitation. CO,CI,SV and LVSWI,decreased with the time after resuscitation,and reached the lowest at 6 hours after resuscitation,but they were lower than those in normal group and before resuscitation. Serum level of TNF-α and IL-6 increased significantly at 2 hours after ROSC,and higher than those in normal group. There were negative correlation between the level of TNF-α,IL-6 and cardiac function parameters. The mRNA expression of myocardial TNF-α and IL-6 in CPR group were significantly higher than those in normal group. Conclusion There was myocardial dysfunction and increasing of TNF-α and IL-6 levels in dogs resuscitated from cardiac arrest. The increase of cytokines is correlated with cardiac dysfunction after resuscitation." @default.
- W2353259780 created "2016-06-24" @default.
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- W2353259780 date "2005-01-01" @default.
- W2353259780 modified "2023-09-23" @default.
- W2353259780 title "The relationship between TNF-α,IL-6 and cardiac dysfunction in dogs resuscitated from cardiac arrest" @default.
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