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- W2353291130 abstract "Objective To evaluate the clinical effect and side-effect of hemapoietic function of the patients with metastatic bone cancer treated by 153Sm-EDTMP. Methods 153Sm-EDTMP dose was 0.5-1.5 mCi/kg per time by intravenous, The changes of life quality, cancer size and hemapoietic function before and after treatment with 153Sm-EDTMP were evaluated. Results After treatment with 153Sm-EDTMP, 32.5%(13/40) patients with pain achieved complete response, 50%(20/40) patients had partial response, up progressives were observed in 17.5%(7/40) patients, total effective rate was 82.5%. With Dose1 mCi, 153Sm-EDTMP administered alone affected more slightly the hemapoiteic fuction of patient's than that with dose 1 mCi, and recovered about four weeks after the treatment. With dose1 mCi or 153Sm-EDTMP combinated with chmotherapy, the hemapoietic fuction was affected more obviouly. When WBC≤2×109/L, using G-CSF and cord blood to improve WBC level, patients recovered about six weeks after the treatment. Conclusion ① 153Sm-EDTMP treatment of metastatic bone cancer was effective, it can control focuses progress, eliminate metastatic bone focus and improve patient's life quality; ② 153Sm-EDTMP affected the hemapoietic function. With dose≥1 mCi, if 153Sm-EDTMP was administered continuously for more than two times for treatment, whole blood was deceased. ③cord blood can be used to improve hemapoietic function. ;" @default.
- W2353291130 created "2016-06-24" @default.
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- W2353291130 date "2006-01-01" @default.
- W2353291130 modified "2023-10-12" @default.
- W2353291130 title "Clinical observation of multiple metastatic bone cancer by ~( 153)Sm-EDTMP" @default.
- W2353291130 hasPublicationYear "2006" @default.
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