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- W2353291856 abstract "Objective To establish a clinic-applicable nerve conduit for efficient repair of oculomotor nerve defect.Methods Twenty-two cats were used in the experiments.A four-millimeter nerve lesion was made in each cat by transecting the cistern segment of the right oculomotor nerve.The nerve lesions were then repaired with PLGA conduit in group A(n=10),with modified PLGA in group B(n=10),and without repairing in group C(n=2).The pupillary light reflex and ocular movement were detected once a week after surgery.Fourteen weeks after surgery,the continuity and regeneration of repaired nerve were examined by light and electronic microscope.Results(75.0%) cases in group A and(77.8%) cases in group B showed partial oculomotor nerve function recovery.The anatomical continuity of repaired nerves was verified by histology.There were no significant differences of the nerve fiber transition ratios and the axonal diameters between group A and B(P(0.05)).No detectable recovery of impaired nerve in group C was found.Conclusion Both PLGA conduit and modified PLGA conduit can efficiently repair cat oculomotor nerve defects.However,the modified PLGA conduit has some advantages,such as easy to use,local administration of medicine,being made from easy-acquired materials,and therefore,is more feasible for clinical application." @default.
- W2353291856 created "2016-06-24" @default.
- W2353291856 creator A5005214097 @default.
- W2353291856 date "2005-01-01" @default.
- W2353291856 modified "2023-09-28" @default.
- W2353291856 title "Repairing cat oculomotor nerve defect with a modified PLGA nerve conduit" @default.
- W2353291856 hasPublicationYear "2005" @default.
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