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- W2353293447 abstract "Objective To observe and compare the effect of Astragaloside IV and Astragalus injection on Caspase-3 positive cells and Caspase-3 mRNA expression of neurons around intracerebral hemorrhage in rats.Methods 128 male SD rats were randomly divided into normal group,model group,Astragalus injection group and Astragaloside IV group.Treatment groups were intraperitoneally injected with Astragaloside IV and Astragalus on 0 h after establishing model,then every 24 h injection was conducted.The normal group and model group were injected saline.Caspase-3 positive cells and Caspase-3 mRNA expression as well as the correlation between the both were observed with by immunohistochemistry and RT-PCR method at 1st d,2nd d,3rd d,7th d respectively.Results Compared with the normal group,Caspase-3 positive cells and Caspase-3 mRNA expression of Astragalus model group,injection groups and Astragaloside IV groups were significantly increased(P0.05).Compared with the model group at the same time,Caspase-3 positive cells and Caspase-3 mRNA expression in Astragaloside IV and Astragalus injection groupat 2nd d,3rd d,7th d were significantly lowered(P0.05).Compared with the 3rd d treatment group,Caspase-3 positive cells and Caspase-3 mRNA expression in Astragaloside IV and Astragalus injection 7th d group were significantly lowered(P0.05).Compared with Astragalus injection 3rd d group,7th d group,Caspase-3 positive cells and Caspase-3 mRNA expression of Astragaloside IV group at the same time were significantly increased(P0.05).Caspase-3 mRNA and Caspase-3 positive cells showed significantly positively correlated(r=0.97,P0.05).Conclusion The Astragaloside and Astragalus injection may inhibited neurons apoptosis of brain hemorrhage in rats through reduction of caspase-3 mRNA transcription and the Caspase-3 protein expression.With the extension of the medication time,the inhibition of neurons apoptotic around rats intracerebral hemorrhage are more obvious.Astragaloside IV inhibition of neurons apoptotic around rats intracerebral hemorrhage is worse than the Astragalus injection." @default.
- W2353293447 created "2016-06-24" @default.
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- W2353293447 date "2013-01-01" @default.
- W2353293447 modified "2023-09-23" @default.
- W2353293447 title "Effect of the Astragalus on Caspase-3 Expression of Neurons Around Intracerebral Hemorrhage in Rats" @default.
- W2353293447 hasPublicationYear "2013" @default.
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