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- W2353328257 abstract "Objective To investigate the effect of Wenshen Qingwei Granule on serum PAIgG,TPO and its receptor c-MPL mRNA changes in patients with ITP.Methods A total of 60 patients were randomly divided into two groups: treatment group in which 30 cases were treated with Wenshen Qingwei Granule and control group in which 30 cases were treated with prednisone;and 20 healthy people were enrolled as normal group.The serum TPO and PAIgG in the two groups were detected by ELISA respectively after one-month,three-month and six-month treatments.The c-MPL mRNA in platelets was determined by semi-quantitative reverse transcription polymerase chain reaction(RT-PCR) in the two groups.Results After one-month treatment,the expressions of TPO and PAIgG in serum were higher and platelets quantity was lower in the treatment group than those in the control group(P0.05 or P0.01);c-MPL mRNA in platelets was of insignificant difference between two groups(P0.05).After three-month and six-month treatments,the TPO and PAIgG in serum were decreased and c-MPL mRNA levels in platelets were increased in the treatment group compared with those in the control group(P0.05 or P0.01),while the platelets quantity was elevated(P0.05 or P0.01).Conclusion Wenshen Qingwei Granule can inhibit PAIgG expression and c-MPL mRNA transcription to increase the platelet production." @default.
- W2353328257 created "2016-06-24" @default.
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- W2353328257 date "2010-01-01" @default.
- W2353328257 modified "2023-09-23" @default.
- W2353328257 title "Clinical research on Wenshen Qingwei Granule in regulating serum thrombopoietin,PAIgG and c-MPL mRNA in patients with idiopathic thrombocytopenic purpura" @default.
- W2353328257 hasPublicationYear "2010" @default.
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