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- W2353334514 abstract "Elevated mucus secretion is not only one important pathologic character of respiratory tract chronic inflammation diseases,but also an important factor for sudden deterioration of patients' condition.The mucin in mucus is mainly the 5AC which is the major mucoprotein phenotype in the research of respiratory tract elevated mucus secretion diseases.Various kinds of inflammation mediators,pathogenic microorganism and active oxygen can activate related transcriptional factors to bind to the right site on the mucin 5AC gene promoter through signal transduction pathways respectively.Then they can promote transduction and the increased synthesis of mucoprotein.The effect of mitogen activator protein kinase pathway(MAPK) and special protein-1 is especially outstanding.Glucocorticoid,tretinoin and thyroxine also participate in the regulation through nuclear receptors.The inter-regulations also exist between signal pathways and transcription factors,and constitute complicated signal transduction network.Understanding the regulation mechanism should be bound to offer important clues for the deeper research of respiratory tract elevated mucus secertion." @default.
- W2353334514 created "2016-06-24" @default.
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- W2353334514 date "2007-01-01" @default.
- W2353334514 modified "2023-09-24" @default.
- W2353334514 title "The regulation of mucin 5AC genetic transcription in chronic inflammation of respiratory tract" @default.
- W2353334514 hasPublicationYear "2007" @default.
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