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- W2353367508 abstract "Objective To detect Helicobacter genus-specific 16SrRNA and H.pylori specific genes in liver samples in patients with chonic hepatitis B,and to investigate whether Helicobacter species play a role in the development of the chronic hepatitis B.Methods Helicobacter were sought by PCR using primers for the 16SrRNA and histology culture in the liver samples from 56 patients with chronic hepatitis B,and H.pylori cagA、vacA and glmM genes were further amplified by specific primers amplification in the samples with Helicobacter genus-16SrRNA positive. Results Helicobacter genus-specific 16SrRNA was found in 35 of 56 samples,and the detection rate in the patients with HCC,chronic cirrhosis were significantly higher than that in the patients with chronic hepatitis (87.5%,72.7% versus 42.3%,P﹤0.05). In the patients with chronic hepatitis,the positive rate increased with the inflammation score. Of the 35 patients,21 were detected positively for H.pylori cagA、vacA and glmM genes by PCR. The other 14 samples were sequenced,and found to have 99.2% similarity to the 16SrRNA of H.hepaticus and 98.7% similarity to the 16SrRNA of H.rodentium,96.9% similarity to the 16SrRNA of H. pullorum,95.2% similarity to the 16SrRNA of H.bilis.Conclusion H.pylori DNA and other helicobacter DNA coexisted in the liver samples of patients with chronic hepatitis B,and they might play a synergistic role in the development of chronic hepatitis to cirrhosis and HCC." @default.
- W2353367508 created "2016-06-24" @default.
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- W2353367508 date "2009-01-01" @default.
- W2353367508 modified "2023-09-24" @default.
- W2353367508 title "Identification of Helicobacter genus-specific 16SrRNA and H. pylori specific genes in liver samples in patients with the chonic hepatitis B" @default.
- W2353367508 hasPublicationYear "2009" @default.
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