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- W2353369521 abstract "Objective To evaluate the prognostic value of N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with sepsis.Methods This was a prospective observational cohort study.Patients with sepsis were included and the demographic data of patients were collected.The serum NT-proBNP levels were determined on admission and on the 3rd day after admission,and hospital mortality was taken as the end point.Using receiver operating characteristic(ROC) curves,we calculated the area under the curve(AUC),95% confidence interval,positive predictive value,and negative value and cutoff value.Logistics regression analyses were used to evaluate the prognostic value of NT-proBNP in patients with sepsis;meanwhile,we adjusted the influence of gender,age,disease severity,the use of vasopressors or mechanical ventilation,and creatinine clearance.Results Fifty sepsis patients with a mean age of 68 years old were enrolled.The hospital mortality was 22%(11 cases),and the creatinine clearance rate of death cases was significantly lower than that of survival cases(P0.05);and the NT-proBNP level at the 3rd day after admission was significantly higher than that of the survival patients(P0.05).In the ROC curves,AUC values of NT-proBNP1,NT-proBNP3 and △NT-proBNP were 0.75,0.9 and 0.87,respectively,while that of acute physiologic and chronic health evaluation Ⅱ(APACHEⅡ) was 0.62;the difference in areas of these curves between NT-proBNP and APACHEⅡ was significantly different(P0.05).Logistics regression analyses showed that NT-proBNP3 was significantly correlated with the prognosis of sepsis(OR=1.000 4,P0.05).The prognostic value of NT-proBNP was not affected by the gender,age,disease severity,vasopressors,mechanical ventilation or creatinine clearance.Conclusion Compared with APACHE Ⅱ score,serial determination of NT-proBNP has a better prognostic value for patients with sepsis.(Shanghai Med J,2010,33: 546-549)" @default.
- W2353369521 created "2016-06-24" @default.
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- W2353369521 date "2010-01-01" @default.
- W2353369521 modified "2023-09-25" @default.
- W2353369521 title "Prognostic value of N-terminal pro-brain natriuretic peptide in patients with sepsis" @default.
- W2353369521 hasPublicationYear "2010" @default.
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