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- W2353374006 abstract "Objective To investigate the expression of CK2α in human endometrial adenocarcinoma and analyze its clinical significance.Methods A total of 36 human endometrial adenocarcinoma and adjacent normal tissue samples were enrolled,aged 44-67 years old,median age 57.5 years old.The endometrial adenocarcinoma were performed 4 clinical staging by Federation International of Gynecology and Obstetrics in 2000: 19 cases were stage Ⅰ(11 cases myometrial invasion ≤ 1/2,8 cases 1/2),9 cases were stage Ⅱ,8 cases were stage Ⅲ and Ⅳ.The histological grading were performed 3 classifications: 11 cases were stageⅠ,15 cases were stageⅡ,10 cases were stage Ⅲ.The expression of CK2α mRNA was detected by reverse transcription-polymerase chain reaction(RT-PCR) and CK2α protein by immunohistochemistry.The positive rate of CK2α protein expression in different groups defined by clinical stage,differentiation degree and muscular invasion were compared.Results The expression of CK2α mRNA and protein in endometrial adenocarcinoma were significantly higher than that in adjacent normal tissues.The positive rate of CK2α protein expression was not related with clinical stage,differentiation degree and muscular invasion.Conclusion It is demonstrated that the increase of CK2α expression could closely related with the onset of human endometrial adenocarcinoma,CK2α may be a potential molecular target for the treatment of the cancer." @default.
- W2353374006 created "2016-06-24" @default.
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- W2353374006 date "2012-01-01" @default.
- W2353374006 modified "2023-09-27" @default.
- W2353374006 title "Expression and significant of CK2α in human endometrial adenocarcinoma" @default.
- W2353374006 hasPublicationYear "2012" @default.
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