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- W2353376168 abstract "In this communication we report the chemical synthesis of a pentanucleotide fragment, CpUpCpGpUp, which corresponds to the part of the 3'-terminal stem of yeast alanine tRNA. By condensing _(HO)U (OBz)-p-NHC_6H_5 with _(MMT)G~(Ac)(OAc)-p or _(MMT)G~(iBu)(OiBu)-p and deblocking the 5'-MMT protecting group, _(HO)G~(Ac)(OAc)-p-U(OBz)-p-NHC_6H_5 and _(HO)G~((?)Bu)(OiBu)-p-U(OBz)-p-NHC_6H_5 can be obtained. _(Bz)C~(Bz)(OBz)-p-U(OBz)p-C~(Bz)(OBz)-p is synthesized by condensing _(Bz)C~(Bz) (OBz)-p-U(OBz)-p, which, in turn, is prepared from _(Bz)C~(Bz)(OBz)-p and _(HO)U (OBz)-p-NHC_6H_5, with _(HO)C~(Bz)(OBz)-p-NHC_6H_5 and deblocking the aniline group. Coupling such a protected trinucleoside triphosphate with _(Ho)G~(Ac)(OAc)-p-U(OBz)-p-NHC-6H_5 and removing all protecting groups gives a crude product. After purification by column chromatography in 7 M urea, pure CpUpCpGpUp is obtained. This product is identified by means of paper electrophoresis, TEAE-thin layer chromatography, and can be completely digested with pancreatic RNase to give Cp, Up, GpUp in the correct ratio." @default.
- W2353376168 created "2016-06-24" @default.
- W2353376168 creator A5011440758 @default.
- W2353376168 date "1978-01-01" @default.
- W2353376168 modified "2023-09-23" @default.
- W2353376168 title "STUDIES ON POLYNUCLEOTIDE SYNTHESIS II. SYNTHESIS OF OpUpOp, GpUp AND OpUpOpGpUp" @default.
- W2353376168 hasPublicationYear "1978" @default.
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