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- W2353393292 abstract "The recrystallization method is an important method to produce micronized drugs. In an one liter flask device, with ethanol and acetone chosen as solvent candidates and distilled water chosen as precipitator, the main factors which might influence the mean particle size and recovery rate of recrystallized ibuprofen were studied in this article. Experimental results show that the optimum recrystallization conditions are as following: ethanol chosen as solvent, 5?℃ or lower temperature, 800?r/min or higher stirring speed, and adding 0.6～0.8?mol/L ibuprofen ethanol solution to water with a volume ratio less than 1∶2 and solution infusion rate less than 8?mL/min. Under such conditions, a product of 4?μm mean particle size and over 92% recovery rate was prepared. The recrystallized product and ibuprofen material were characterized by XRD and SEM techniques. Furthermore, a dissolution experiment proved the advantages of the recrystalllized product." @default.
- W2353393292 created "2016-06-24" @default.
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- W2353393292 date "2003-01-01" @default.
- W2353393292 modified "2023-09-23" @default.
- W2353393292 title "A recrystallization method for improving ibuprofen dissolution" @default.
- W2353393292 hasPublicationYear "2003" @default.
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