Matches in SemOpenAlex for { <https://semopenalex.org/work/W2353393671> ?p ?o ?g. }
- W2353393671 abstract "Discovery of histone lysine specific demethylase 1 (LSD1) indicates that even histone methylation is reversible. Structural analysis shows that LSD1 is a flavin-dependent amine oxidase, which is able to catalyze the specific removal of methyl groups from mono- and dimethylated Lys4 and Lys9 of histone H3. Functional studies demonstrate that LSD1 regulates activation and inhibition of gene transcription in the nucleus, which is known as the innermost gene switch of cells. LSD1 plays important roles in embryonic development and tumorigenesis. Here, we review recent insights into the structure and chemical mechanism of LSD1, and its regulatory roles in development and cancer." @default.
- W2353393671 created "2016-06-24" @default.
- W2353393671 creator A5009075216 @default.
- W2353393671 creator A5012793137 @default.
- W2353393671 creator A5043712148 @default.
- W2353393671 creator A5055494772 @default.
- W2353393671 creator A5064320011 @default.
- W2353393671 creator A5068817730 @default.
- W2353393671 date "2010-04-30" @default.
- W2353393671 modified "2023-10-04" @default.
- W2353393671 title "Histone demethylase LSD1 and its biological functions" @default.
- W2353393671 cites W1933216594 @default.
- W2353393671 cites W1965027943 @default.
- W2353393671 cites W1970250447 @default.
- W2353393671 cites W1977851507 @default.
- W2353393671 cites W1980267772 @default.
- W2353393671 cites W1980673831 @default.
- W2353393671 cites W1981354816 @default.
- W2353393671 cites W1983015568 @default.
- W2353393671 cites W1989320965 @default.
- W2353393671 cites W1996287615 @default.
- W2353393671 cites W2001858515 @default.
- W2353393671 cites W2002676132 @default.
- W2353393671 cites W2005960411 @default.
- W2353393671 cites W2006989482 @default.
- W2353393671 cites W2008735740 @default.
- W2353393671 cites W2008922065 @default.
- W2353393671 cites W2011482055 @default.
- W2353393671 cites W2016018631 @default.
- W2353393671 cites W2017188188 @default.
- W2353393671 cites W2017790794 @default.
- W2353393671 cites W2022884475 @default.
- W2353393671 cites W2024634513 @default.
- W2353393671 cites W2034084795 @default.
- W2353393671 cites W2038994163 @default.
- W2353393671 cites W2040365591 @default.
- W2353393671 cites W2041165979 @default.
- W2353393671 cites W2048958290 @default.
- W2353393671 cites W2050723217 @default.
- W2353393671 cites W2052859691 @default.
- W2353393671 cites W2053601500 @default.
- W2353393671 cites W2054621094 @default.
- W2353393671 cites W2054643318 @default.
- W2353393671 cites W2058223580 @default.
- W2353393671 cites W2059255388 @default.
- W2353393671 cites W2060725084 @default.
- W2353393671 cites W2060733408 @default.
- W2353393671 cites W2064887977 @default.
- W2353393671 cites W2066305078 @default.
- W2353393671 cites W2068157186 @default.
- W2353393671 cites W2072677280 @default.
- W2353393671 cites W2076446466 @default.
- W2353393671 cites W2086989609 @default.
- W2353393671 cites W2087362720 @default.
- W2353393671 cites W2091232875 @default.
- W2353393671 cites W2096083625 @default.
- W2353393671 cites W2103255565 @default.
- W2353393671 cites W2106921118 @default.
- W2353393671 cites W2120450507 @default.
- W2353393671 cites W2121842901 @default.
- W2353393671 cites W2130211801 @default.
- W2353393671 cites W2133148543 @default.
- W2353393671 cites W2139008292 @default.
- W2353393671 cites W2142303705 @default.
- W2353393671 cites W2158747282 @default.
- W2353393671 cites W2159854469 @default.
- W2353393671 cites W2004499293 @default.
- W2353393671 doi "https://doi.org/10.3724/sp.j.1005.2010.00331" @default.
- W2353393671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20423886" @default.
- W2353393671 hasPublicationYear "2010" @default.
- W2353393671 type Work @default.
- W2353393671 sameAs 2353393671 @default.
- W2353393671 citedByCount "6" @default.
- W2353393671 countsByYear W23533936712014 @default.
- W2353393671 countsByYear W23533936712015 @default.
- W2353393671 countsByYear W23533936712019 @default.
- W2353393671 countsByYear W23533936712020 @default.
- W2353393671 countsByYear W23533936712023 @default.
- W2353393671 crossrefType "journal-article" @default.
- W2353393671 hasAuthorship W2353393671A5009075216 @default.
- W2353393671 hasAuthorship W2353393671A5012793137 @default.
- W2353393671 hasAuthorship W2353393671A5043712148 @default.
- W2353393671 hasAuthorship W2353393671A5055494772 @default.
- W2353393671 hasAuthorship W2353393671A5064320011 @default.
- W2353393671 hasAuthorship W2353393671A5068817730 @default.
- W2353393671 hasConcept C10058791 @default.
- W2353393671 hasConcept C104317684 @default.
- W2353393671 hasConcept C150194340 @default.
- W2353393671 hasConcept C150425827 @default.
- W2353393671 hasConcept C190727270 @default.
- W2353393671 hasConcept C22709980 @default.
- W2353393671 hasConcept C2776745794 @default.
- W2353393671 hasConcept C2781364455 @default.
- W2353393671 hasConcept C50171091 @default.
- W2353393671 hasConcept C54355233 @default.
- W2353393671 hasConcept C55493867 @default.
- W2353393671 hasConcept C56428682 @default.
- W2353393671 hasConcept C64927066 @default.
- W2353393671 hasConcept C84772758 @default.
- W2353393671 hasConcept C86803240 @default.