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- W2353399654 abstract "Objective To observe the effects of breviscapine on the expression MyD88 and TNF-α in rat peritoneal mesothelial cells(RPMCS) stimulated by high glucose. Methods RPMCS were isolated after tissue enzymatic digested, cultured and identified by phase contrast inverted and immunocytochemistry method. Cells of the third generation were divided into 3 groups:(1) control group;(2) cells grew in glucose concentration of1.5%, 2.5%, 4.25% for 4, 6 and 8 h;(3) after stimulated by glucose of three different concentration for 6 h,cells were treated with breviscapine for 8 h. The proliferation of RPMCS in each group was examined by MTT colorimeric assay. MyD88, TNF-α in medium of each group were assayed by ELISA. Results The value of OD of RPMCS reduced compared with control group after stimulated by dialysis solution which contained glucose and it was statistically significant(P 0.01). Such reduction was more manifest with higher concentration glucose and longer treatment time( P 0. 05). When treated with breviscapine, the value of OD of each group increased( P 0.05). Compared with control group the cells′ expression of MyD88 and TNF-α significantly increased(P 0.01). After treated with breviscapine the expression of the two target value of each group decreased(P 0.05).Conclusions High concentration glucose inhibits the proliferation of RPMCS in vitro and increases the expression of MyD88 and TNF-α. Erigeron can alleviate inhibition of the high concentration glucose and decrease the expression of inflammatory factors. It indicated breviscapine could improve peritonitis and protect peritoneal function." @default.
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- W2353399654 date "2013-01-01" @default.
- W2353399654 modified "2023-09-27" @default.
- W2353399654 title "Effects of breviscapine on the expression of MyD88 and TNF-α in rat peritoneal mesothelial cells stimulatedby high glucose" @default.
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