Matches in SemOpenAlex for { <https://semopenalex.org/work/W2353414587> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2353414587 abstract "Objective To investigate the anti-tumor effects and mechanisms of paeonol(Pae) combined with 5-Fluorouracil(5-Fu) treatment for nude mice loaded human carcinoma of Bel-7404 cells.Methods The tumor model was established by subcutaneously injecting human carcinoma of Bel-7404 cells to right forearm armpits.Nude mice loaded Bel-7404 cells were randomly divided into 4 groups(5 in each group):①Control group: equal volume NS intraperitoneal injection every two days for 10 days;②5-Fu group: 20 mg/kg,intraperitoneal injection every two days for 10 days;③Pae group:100 mg/kg,intraperitoneal injection every two days for 10 days;④Pae+5-Fu group: Pae 100 mg/kg and 5-Fu 20 mg/kg intraperitoneal injection every two days for 10 days.We observed the tumor volumes and weights in each group.Telomerase activity was examined by PCR-TRAP.The expression of human telomerase reverse transcriptase(hTERT) mRNA and protein were analyzed by RT-PCR and Western blot,respectively.Results After the intervention of Pae,5-Fu,and their combination therapy,tumor volume and quality of decreased significantly compared with the control group,the tumor-inhibitory rates were 45.32%,60.79% and 80.22 %,respectively.The results of PCR and Western blot showed that Pae,5-Fu,and their combination therapy all could significantly suppress telomerase activity,and down-regulate mRNA and protein levels of hTERT.Conclusion Pae has a synergistic anti-tumor effect with 5-Fu and the mechanism may be related to reduced telomerase activity and hTERT expression." @default.
- W2353414587 created "2016-06-24" @default.
- W2353414587 creator A5030711242 @default.
- W2353414587 date "2011-01-01" @default.
- W2353414587 modified "2023-09-23" @default.
- W2353414587 title "Anti-tumor Effects and Mechanisms of Paeonol Combined with 5-Fluorouracil Treatment for Nude Mice Transplanted Human Hepatic Carcinoma" @default.
- W2353414587 hasPublicationYear "2011" @default.
- W2353414587 type Work @default.
- W2353414587 sameAs 2353414587 @default.
- W2353414587 citedByCount "0" @default.
- W2353414587 crossrefType "journal-article" @default.
- W2353414587 hasAuthorship W2353414587A5030711242 @default.
- W2353414587 hasConcept C104317684 @default.
- W2353414587 hasConcept C121608353 @default.
- W2353414587 hasConcept C125593758 @default.
- W2353414587 hasConcept C126322002 @default.
- W2353414587 hasConcept C142724271 @default.
- W2353414587 hasConcept C185592680 @default.
- W2353414587 hasConcept C204787440 @default.
- W2353414587 hasConcept C2776415932 @default.
- W2353414587 hasConcept C2778833331 @default.
- W2353414587 hasConcept C2780159080 @default.
- W2353414587 hasConcept C2780278673 @default.
- W2353414587 hasConcept C2780456651 @default.
- W2353414587 hasConcept C55493867 @default.
- W2353414587 hasConcept C71924100 @default.
- W2353414587 hasConcept C94581717 @default.
- W2353414587 hasConcept C98274493 @default.
- W2353414587 hasConceptScore W2353414587C104317684 @default.
- W2353414587 hasConceptScore W2353414587C121608353 @default.
- W2353414587 hasConceptScore W2353414587C125593758 @default.
- W2353414587 hasConceptScore W2353414587C126322002 @default.
- W2353414587 hasConceptScore W2353414587C142724271 @default.
- W2353414587 hasConceptScore W2353414587C185592680 @default.
- W2353414587 hasConceptScore W2353414587C204787440 @default.
- W2353414587 hasConceptScore W2353414587C2776415932 @default.
- W2353414587 hasConceptScore W2353414587C2778833331 @default.
- W2353414587 hasConceptScore W2353414587C2780159080 @default.
- W2353414587 hasConceptScore W2353414587C2780278673 @default.
- W2353414587 hasConceptScore W2353414587C2780456651 @default.
- W2353414587 hasConceptScore W2353414587C55493867 @default.
- W2353414587 hasConceptScore W2353414587C71924100 @default.
- W2353414587 hasConceptScore W2353414587C94581717 @default.
- W2353414587 hasConceptScore W2353414587C98274493 @default.
- W2353414587 hasOpenAccess W2353414587 @default.
- W2353414587 hasRelatedWork W2184224810 @default.
- W2353414587 hasRelatedWork W2348799567 @default.
- W2353414587 hasRelatedWork W2354189070 @default.
- W2353414587 hasRelatedWork W2356481950 @default.
- W2353414587 hasRelatedWork W2359107428 @default.
- W2353414587 hasRelatedWork W2359913422 @default.
- W2353414587 hasRelatedWork W2361496678 @default.
- W2353414587 hasRelatedWork W2362923964 @default.
- W2353414587 hasRelatedWork W2366271449 @default.
- W2353414587 hasRelatedWork W2369071974 @default.
- W2353414587 hasRelatedWork W2372472785 @default.
- W2353414587 hasRelatedWork W2373660558 @default.
- W2353414587 hasRelatedWork W2383965654 @default.
- W2353414587 hasRelatedWork W2385410762 @default.
- W2353414587 hasRelatedWork W2388762021 @default.
- W2353414587 hasRelatedWork W2389631441 @default.
- W2353414587 hasRelatedWork W2389789178 @default.
- W2353414587 hasRelatedWork W2390675486 @default.
- W2353414587 hasRelatedWork W3032577532 @default.
- W2353414587 hasRelatedWork W1824085087 @default.
- W2353414587 isParatext "false" @default.
- W2353414587 isRetracted "false" @default.
- W2353414587 magId "2353414587" @default.
- W2353414587 workType "article" @default.