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- W2353417047 abstract "Objective To observe the curative effect of soaking-washing with self-designed TCM formula on oxaliplatin-induced peripheral neurotoxicity.Methods The patients(n =35) who had peripheral neurotoxicity after chemotherapy containing oxaliplatin plan were given soaking-washing with self-designed TCM formula for 14 days.The grading changes of peripheral neurotoxicity,score changes of Karnofsky performance scale(KPS),median time to the evaluation standard of cured/effective,and adverse reactions were observed in the patients.Results Before the treatment,the grading of peripheral neurotoxicity in 35 patients showed that there were 10 cases with grade I(28.6%),18 with grade II(51.4%) and 7 with grade III(20.0%).After the treatment,the grading showed that there were 10 cases with grade 0(28.6%),16 with grade I(45.7%),6 with grade II(17.1%) and 3 with grade III(8.6%).The difference was statistical significant before and after the treatment(P 0.05),and peripheral neurotoxicity was decreased after the treatment.The changes of grading of peripheral neurotoxicity in 35 patients showed that there were 10 cases cured(28.6%),19 with effectiveness(54.3%),and 6 without effectiveness(17.1%).The total effective rate was 82.9%.The score of KPS was(71.7±5.7) before the treatment and(80.0±7.7) after the treatment(P 0.05).The changes of KPS score showed that the score was increased in 27 cases(77.1%) and stabilized in 8(22.9%),and the total effective rate was 77.1%.Among 35 patients,there were 29 had reached the evaluation standard of cured/effective and the median time was(6.9±2.5) day.There were no any adverse reactions observed in all patients.Conclusion The soaking-washing with self-designed TCM formula has a good curative effect on oxaliplatin-induced peripheral neurotoxicity." @default.
- W2353417047 created "2016-06-24" @default.
- W2353417047 creator A5038579634 @default.
- W2353417047 date "2012-01-01" @default.
- W2353417047 modified "2023-09-23" @default.
- W2353417047 title "Treatment of oxaliplatin-induced peripheral neurotoxicity with soaking-washing with Chinese medicinals" @default.
- W2353417047 hasPublicationYear "2012" @default.
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