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- W2353419630 abstract "Objective To investigate the effects and mechanisms of tauroursodeoxycholic acid(TUDCA)on human lens epithelial cells(hLECs)in a high glucose medium.Methods HLECs were incubated in DMEM with different concentrations of glucose for 24 h.A model of apoptotic hLECs was established and exposed to TUDCA(0.2,0.5,1.0,2.0 mmol/L)for 24 h.The proliferation of hLECs was determined by MTT.Morphologic evaluation of apoptotic cells was performed by Hoechst 33258 staining and the apoptosis rate was measured by flow cytometry(FCM)after staining of Annexin V-FITC and PI.Western blot was used to determine the expression of GRP78.Results After glucose treatment for 24 h,the inhibition of cell proliferation was increased with glucose concentration increasing(P0.01).Incubating the cells with high concentration of glucose(250 mmol/L)for 24 h inhibited the proliferation of hLECs and induced significant cells apoptosis(P0.01).The Apoptosis percentage of hLECs was decreased and expression of Bip/GRP78 was markedly inhibited after coincubation with TUDCA(P0.05).Conclusions Endoplasmic reticulum stress is involved in hLECs apoptosis induced by a high concentration of glucose.TUDCA inhibits hLECs apoptosis,thus protecting hLECs in vitro.The signal transduction mechanisms are related to endoplasmic reticulum stress." @default.
- W2353419630 created "2016-06-24" @default.
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- W2353419630 date "2010-01-01" @default.
- W2353419630 modified "2023-09-23" @default.
- W2353419630 title "Protective effects of tauroursodeoxycholic acid on human lens epithelial cells in a high glucose environment" @default.
- W2353419630 hasPublicationYear "2010" @default.
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