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- W2353422013 abstract "To study the role of lipid peroxidation during hepatic ischemia-reperfusion injury (HIRI) and the effects of L-Arginine (L-Arg).The rabbits and patients who underwent elective hepatic surgery were randomly divided into two groups respectively, HIRI group and L-Arg group.Plasma malondialdehyde (MDA) and alanine aminotransferase (ALT) were measured before ischemia 45 minutes (rabbits) or 25 minutes(patients) and 45 minutes(rabbits) or 25 minutes (patients) after reperfusion.As compared with pre-ischemia, MDA and ALT increased during ischemia 45 minutes (or 25 minutes) in rabbits and patients, P<0.05 or P<0.01. Treatment with L-Arg could markedly reduce the elevation of mentioned biochemical parameters during hepatic ischemia. In rabbits MDA decreased on hepatic but the different were not significant (P>0.05), ALT decreased (P<0.05). In patients MDA and ALT both decreased on hepatic(both P<0.01). After reperfusion, MDA and ALT all decreased in rabbits and patients (all P<0.01).These data suggest that lipid peroxidation can play an important role in the happening and developing of HIRI. Treatment with L-Arg may attenuate ischemia-reperfusion injury by antagonizing lipid peroxidation." @default.
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- W2353422013 date "2003-02-01" @default.
- W2353422013 modified "2023-09-23" @default.
- W2353422013 title "[Role of lipid peroxidation in hepatic ischemia-reperfusion injury and effect of L-Arginine]." @default.
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