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- W2353436053 abstract "Objective: To observe the influences of chronic exposure of gaseous formaldehyde on the ovarian function of mice and the expression of Foxl2 and Fshr and Esr2 mRNA in the local ovarian in order to explore reproductive toxicity of gaseous formaldehyde.Methods:Twenty sexually mature Kunming female mice of SPF level were randomly divided into control group and chronic gaseous formaldehyde exposure group.The control group was given intraperitoneal injection of saline,the exposure group were given gaseous formaldehyde at dosage of 1.0 mg/m3 for dynamic inhalation,6h/d for a consecutive 14 days.Estrous cycle of the mice was observed,mice were sacrificed through cervical dislocation at the end of the experiment,then ovaries were taken and organic coefficient of ovarian was calculated.Serum sex hormone levels were determined by Radioimmunoassay,and expression levels of Foxl2 and Fshr and Esr2 in ovarian tissues were detected by means of Reverse transcription-polymerase chain reaction and Real-time quantitative polymerase chain reaction.Results:The organic coefficient of ovarian in the exposure group were significantly reduced showing significant difference comparing with the control group(P0.05).The levels of serum FSH and LH in the exposure group were obviously increased,while the levels of E2 were obviously decreased,all significantly different from that of the control group(P0.05 or 0.01).No significant difference in the levels of FSH/LH was observed between the two groups.The expressions of Foxl2 and Fshr mRNA were increased in the exposure group,but the levels of Esr2 mRNA were decreased and the differences were statistically significant compared with the control group(P0.01 or P0.05).Conclusion:Chronically exposure to gaseous formaldehyde at the dosage of 1.0 mg/m3 concentration could diminish ovarian reserve in mice and would affect the expression level of Foxl2 and Fshr and Esr2 mRNA in the local ovarian." @default.
- W2353436053 created "2016-06-24" @default.
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- W2353436053 date "2012-01-01" @default.
- W2353436053 modified "2023-09-28" @default.
- W2353436053 title "Expressions of Foxl2,Fshr and Esr2 mRNA in mice ovarian chronically exposed to gaseous formaldehyde" @default.
- W2353436053 hasPublicationYear "2012" @default.
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