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- W2353449307 abstract "Objective To investigate the anti cancer mechanism of interferon α 2b by studying the changes of telomerase activity and c myc expression in human liver cancer cell SMMC 7721. Methods The human liver cancer cell SMMC 7721 in culture was treated by interferon α 2b of two concentrations, 1000 IU/ml and 5000 IU/ml. After 1,3,5,9 days, PCR based TRAP (telomere repeat amplification protocol) was used to detect the changes of telomerase activity and the expression of c myc protein observed by immuno histochemistry. Results Interferon inhibited the activity of telomerase and expression of c myc protein. The immunoactivity of c myc protein was inhibited obviously at 1 st day and almost completely inhibited at 5 th day. There is no difference between the two doses. The inhibition of telomerase accurred later than the expression change of c myc protein. Telomerase activity was obviously inhibited on 5 th day at the dose of 1000 IU/ml and completely inhibited on 9 th day. The complete suppression was also observed on 5 th day at the dose of 5000 IU/ml. Conclusion Telomerase, an RNA dependent DNA polymerase which was used by cancer cells to solve the continued shortened telomeres caused by end replication. Activation and up regulation of telomerase are considered important in the genesis and development of cancer. hTERT has important relationship with telomerase activity. There have been c myc protein linkages sites in the promoter field of the hTERT, the up regulated c myc results in high telomerase activity. The expression of c myc protein was inhibited by the interferon α 2b earlier than the inhibition of telomerase activity, so the telomerase activity inhibition by interferon α 2b is very possiblly through the suppression of c myc.(Shanghai Med J, 2001,24∶137)" @default.
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- W2353449307 date "2001-01-01" @default.
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- W2353449307 title "The inhibition of telomerase activity and c-myc expression in SMMC-7721 liver cancer cell by interferon #alpha#-2b" @default.
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