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- W2353450194 abstract "Objective To study the level and heritability of serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) in adult twins sampled from Qingdao City of China. Methods 316 pairs of healthy twin aged 18 to 60 years were recruited from the database of Qingdao City twin registry. Fasting serum lipids were detected by automatic biochemical analyzer. The zygosity of twins was established by using polymorphic DNA-based microsatellite markers. The heritability was estimated by formulating univariate ACE twin mode in Mx soft. Results The average levels of fasting serum TC, HDL-C, LDL-C and TG were (4.52 +/- 1.08), (1.46 +/- 0.39), (2.58 +/- 0.79) and (1.11 +/- 0.77) mmol/L, respectively. The best fitting models adjusted by sex and age in Mx soft were AE model for TC, HDL-C and LDL-C, whereas CE model for TG. The heritability of TC, HDL-C, LDL-C and TG were 53% , 62% , 57% and 0, respectively. Conclusion It is considered that both genetic and environmental factors may influence the level of TC, HDL-C and LDL-C, whereas environmental effect may be the factor essential for the level of TG." @default.
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- W2353450194 date "2010-05-01" @default.
- W2353450194 modified "2023-09-29" @default.
- W2353450194 title "Heritability analysis on serum lipids of adult twins in Qingdao City" @default.
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