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- W2353463814 abstract "Objective To investigate the profective effect of an inhibitor of NOS (N-nitro-L-arginine methyl ester, L-NAME) on experimental murine acute viral myocarditis (AVM) at different stages. Methods 130 male Balb/C mice (15 - 16 g) were divided into 4 groups randomly: one normal control group, three viral control groups (administered injective water after intraperitoneal CVB3m) , three interference control groups (administered L-NAME 5 mg·kg-1·d-1 after intraperitoneal CVB3m cultive fluid) , six interference experimental groups (administered L-NAME 5 mg·kg-1·d-1 after intraperitoneal CVB3m). Their blood and hearts were sacrificed at 7th, 14th, 21st day after CVB3m infection to perform the serum NO level mesurement, histopathological study, iNOS immunohistochemical examination and iNOS-mRNA express level detection. Results (1) The more expression of iNOS and iNOSmRNA was found in the cardiac muscle after CVB3m infection but no expression in normal mice, the increased expression of which was related to the myocardial damage extent. (2) There were more expressions of iNOS and iNOSmRNA in the cardiac muscle in L-NAME-treated mice than those in viral control mice after CVB3m infection, but no expression in normal mice and interference control mice. (3) The improvement of myocardial damage was more obvious in the mice L-NAME-treated from 0, 7th day than that in the mice L-NAME-treated from 14th day after CVB3m infected. (4) There was no obvious myocardial damage in L-NAME treated control groups. Conclusion (1) Aboundance of iNOS protein and iNOS-mRNA were expressed and serum level of NO increased in myocardial damage areas. (2) Intraperitoneal injection of NOS inhibitor L-NAME could inhibit the expression of iNOS and iNOS-mRNA in AVM mice's cardiac muscle. (3) The protective effect was found in the mice L-NAME-treated from 0,7th day, but was not in the mice L-NAME-treated from 14th day after CVB3m infected. (4) Intraperitoneal injection of L-NAME 5 mg·kg-1·d-1 in a short time was not found any harm to those male Balb/C mice." @default.
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- W2353463814 date "2004-01-01" @default.
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- W2353463814 title "Effect of L-NAME on experimental murine acute viral myocarditis at different stages" @default.
- W2353463814 hasPublicationYear "2004" @default.
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