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- W2353472698 abstract "ObjectiveTo investigate the pharmacological properties of etomidate (ET) in the dissociated rat sacral dorsal commissural nucleus (SDCN) neurons. MethodsNystatin perforated patch recording technique under voltage-clamp conditions was used. ResultsAt the holding potential of -40 mV, ET evoked inward current (I_(ET)) over the concentration range of 10 μmol/L to 3 mmol/L with the EC_(50) value of (33.35 ± 3.07) μmol/L. The I_(ET) was suppressed by bicuculline, the selective GABA_(A) receptor antagonist, and picrotoxin a selective blocker of Cl~(-) channel, in a concentration-dependent manner. ConclusionThe results indicate that ET acts on GABA_(A) receptors to result in the opening of the Cl~(-) channels in the SDCN neurons, which may contribute to its general anesthesia at spinal level." @default.
- W2353472698 created "2016-06-24" @default.
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- W2353472698 date "2004-01-01" @default.
- W2353472698 modified "2023-09-24" @default.
- W2353472698 title "Activation of GABA_(A) receptor-gated chloride currents by etomidate in rat sacral dorsal commissural neurons" @default.
- W2353472698 hasPublicationYear "2004" @default.
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