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- W2353472979 abstract "ObjectiveTo investigate the effects of Bccillus Calmette Guerin(BCG)vaccine on anti-tuberculosis and CD4+CD8+ double positive(DP)T lymphocytes.Methods60 SD rats with negative PPD skin tests were randomly divided into the following 3 groups:①BCG group;②BCG-TB group;Rats were infected by mycobacterium tuberculosis(Mtb)3 months after the rats received BCG vaccine;③TB(tuberculosis)group.Mortality of each group was measured.Peripheral CD3+、CD4+、CD8+ and DP T lymphocytes were measured at the beginning and the end of 3rd、4th、5th、6th、8th month of the experiment.Results①Mortality of TB group is 45%(9/20),higher than that of the other two groups(0/40);②CD8+ and DP T lymphocyte subset of BCG group increased significantly at the end of 3rd month;③Although ratio of CD4/CD8(without CD4+)decreased,peripheral CD8+ and DP T lymphocytes increased significantly at the end of 1st month after rats were infected with Mtb;④Ratio of CD4/CD8(may with CD4+ or CD3+)decreased while CD8+、DP T lymphocytos increased significantly in TB group.Conclusion①DP T cell conducts protective immunological effects against tuberculosis;②Expression of CD8+ on CD4+ SP T cell may correlate with the comforming of DP T cell." @default.
- W2353472979 created "2016-06-24" @default.
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- W2353472979 date "2007-01-01" @default.
- W2353472979 modified "2023-09-24" @default.
- W2353472979 title "Impact of BCG Vaccine on Anti-tuberculosis and CD4~+ CD8~+ Double Positive T Lymphocyte Subset in Rats" @default.
- W2353472979 hasPublicationYear "2007" @default.
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